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ELECTROCHEMOTHERAPY
A
combination of electroporation and a chemotherapeutic drug, termed
electrochemo-therapy, leads to a
significant increase of the antitumor effect of the drug. The
Cliniporator device, developed in our laboratory in collaboration
with partners from France, Germany, Italy, Denmark and Belgium
within the 5th EU framework, is currently efficient for treatment of
cutaneous and subcutaneous tumors. To allow for treatment of the
tumors deeper in the body, either during surgery or with endoscopic
electrodes, we are developing a system for synchronization of the
pulses with the ECG signal. This system, which will be a component
of the future generation of clinical electroporation devices, is
being tested in collaboration with the Institute of Oncology in
Ljubljana.
We
are also involved in the development of standard procedures for
clinical electrochemotherapy. We have developed a database and a
web-based medical record system for clinical trials of
electrochemotherapy with the purpose of accelerating the
establishment of the therapy and the experience sharing among the
medical centers in Europe.
Bibliography:
- Cemazar M, Miklavcic D, Mir LM, Belehradek JJr, Bonnay M,
Fourcault D, Sersa G. Electrochemotherapy of tumours resistant
to cisplatin: a study in a murine tumour model. Eur. J.
Cancer 37: 1166-1172, 2001. [PDF
 ]
- Macek-Lebar A, Sersa G, Kranjc S, Groselj A, Miklavcic D.
Optimisation of pulse parameters in vitro for in vivo
electrochemotherapy. Anticancer Res. 22: 1731-1736,
2002. [PDF]
- Pucihar G, Mir LM, Miklavcic D. The effect of pulse
repetition frequency on the uptake into electropermeabilized cells
in vitro with possible applications in electrochemotherapy.
Bioelectrochemistry 57: 167-172, 2002. [PDF]
- Flisar K, Puc M, Kotnik T, Miklavcic D. Cell membrane
electropermeabilization with arbitrary pulse waveforms.
IEEE Eng. Med. Biol. 22(1): 77-81, 2003. [PDF]
- Pavlovic I, Kramar P,
Corovic S, Cukjati D, Miklavcic D. A web application that
extends functionality of medical device for tumor treatment by
means of electrochemotherapy. Radiol.
Oncol. 38: 49-54, 2004. [PDF]
- Puc M, Corovic
S, Flisar K, Petkovsek M, Nastran J, Miklavcic D.
Techniques of signal generation required for
electropermeabilization. Survey of electropermeabilization devices.
Bioelectrochemistry 64: 113-124, 2004. [PDF]
-
Miklavcic D, Kotnik T.
Electroporation for electrochemotherapy and gene therapy.
In Rosch PJ, Markov MS, Bioelectromagnetic Medicine,
Marcel Dekker, New York, 2004, pp. 637-656. [PDF]
-
Sersa G, Cemazar M, Miklavcic D, Rudolf Z.
Electrochemotherapy of tumours.
Radiol. Oncol. 40: 163-174, 2006.
[PDF]
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