Laboratory of Biocybernetics



	Faculty of Electrical Engineering :: Laboratory of Biocybernetics :: Projects

current research
(international)

current research
(slovenian)

other current
projects

recent research

PROJECTS

1. CURRENT RESEARCH PROJECTS

1.1. International

Croatian-Slovenian Cooperation in Science and Technology: Safety Aspects of Electrochemotherapy for Patients with Implanted Devices: Numerical Models and Bench Testing (2016-2017)

Croatian partner:	Dr. Igor Lackovic, Faculty of El. & Comp. Eng., University of Zagreb, Croatia
Slovenian partner:	Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana
Funding:	Slovenian Research Agency (ARRS), Slovenia

BME-ENA: Biomedical Engineering Education Tempus Initiative in Eastern Neighbouring Area (2013-2016)

Project coordinator:	Prof. Nicolas Pallikarakis, University of Patras, Greece
Slovenian partner:	Assoc. Prof. Tomaz Jarm, Faculty of Electrical Eng., University of Ljubljana
Other partners:	Partners from seven EU and 4 non-EU Eastern European countries
Funding:	European Commission, Brussels, Belgium Slovenian Research Agency (ARRS), Slovenia

Austrian-Slovenian Scientific Cooperation: In Vitro Synthesis of Membrane Proteins into Synthetic Polymer Structures for Insertion into Cell Membrane by Electroporation (2016-2017)

Austrian partner:	Prof. Eva-Kathrin Sinner, Institute for Synthetic Bioarchitectures, University of Natural Resources and Life Sciences, Vienna, Austria
Slovenian partner:	Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana
Funding:	Slovenian Research Agency (ARRS), Slovenia

French-Slovenian Scientific Cooperation (PROTEUS programme): Comparison of Electroporation Using Classical and Nanosecond Electric Pulses on Excitable and Nonexcitable Cells and Tissues (2016-2017)

French partner:	Dr. Rodney Philipp O'Connor, LABEX Sigma-Lim – XLIM, Faculté des Sciences et Techniques, Limoges, France
Slovenian partner:	Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana
Funding:	National Centre of Scientific Research (CNRS), France Slovenian Research Agency (ARRS), Slovenia

USA-Slovenian Scientific Cooperation: Planar Lipid Bilayers Exposed to Nanosecond Pulsed Electric Field (2016-2017)

US partner:	Prof. Thomas P. Vernier, Old Dominion University, Frank Reidy Research Center for Bioelectrics, Norfolk, Virginia, USA
Slovenian partner:	Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana
Funding:	Slovenian Research Agency (ARRS), Slovenia

Austrian-Slovenian Lead Agency Joint Project: Electroporation as Method for Inserting Functional Membrane Proteins in Mammalian Cells (2015-2017)

Austrian partner:	Prof. Eva-Kathrin Sinner, Institute for Synthetic Bioarchitectures, University of Natural Resources and Life Sciences, Vienna, Austria
Slovenian partner:	Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana
Funding:	Austrian Science Fund (FWF), Austria Slovenian Research Agency (ARRS), Slovenia

COST TD1104: European network for development of electroporation-based technologies and treatments (EP4Bio2Med) (2011-2016)

Participating countries:	Algeria, Argentina, Australia, Belgium, Bosnia and Herzegovina, Bulgaria, Croatia, Cyprus, Denmark, Finland, France, FYR Macedonia, Germany, Greece, Great Britain, Hungary, Iceland, Ireland, Israel, Italy, Lithuania, Morocco, Netherlands, New Zealand, Norway, Poland, Portugal, Romania, Russian Federation, Serbia, Slovenia, Spain, Sweden, Switzerland, Turkey, Ukraine, United States of America
Funding:	European Commission, Brussels, Belgium

LEA EBAM: European Laboratory of Pulsed Electric Fields Applications
in Biology and Medicine (2011-2018)

French partners:	Dr. Lluis Mir, Lab. of Vectorol. and Antitumor Ther., IGR, Villejuif Prof. Jean-Philippe Girard, Lab. of Pharmacol. and Struct. Biol., IPBS, Toulouse Prof. Yves Fort, Lab. of Complex Molecular Structures, SRSMC, Nancy Dr. Dominique Cros, Laboratory XLIM, Limoges
Slovenian partners:	Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana Prof. Gregor Sersa, Institute of Oncology, Ljubljana
Funding:	National Centre of Scientific Research (CNRS), France University of Ljubljana, Slovenia Institute of Oncology, Ljubljana, Slovenia

German-Slovenian Scientific Cooperation: High Electric Field Diagnostics of Intracellular Organelles (2005-)

German partner:	Prof. Eberhard Neumann, University of Bielefeld, Germany
Slovenian partner:	Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana
Funding:	Gesellschaft für Technologietranfer in der Universität Bielefeld, Germany

1.2. Slovenian [back to the top]

Research Programme: Electroporation-Based Technologies and Treatments (2015-2020)

Programme head:	Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana
Funding:	Slovenian Research Agency (ARRS), Slovenia

Infrastructure Programme: Network of research infrastructure centers at University of Ljubljana (2015-2020)

Programme head:

Prof. Martin Copic, University of Ljubljana

Center head at FE:	Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana
Funding:	Slovenian Research Agency (ARRS), Slovenia

Development and Validation of Treatment Planning Methods for Treating Cancer with Electroporation Based Therapies (2015-2017)

Principal investigator:	Assist. Prof. Bor Kos, Faculty of Electrical Eng., University of Ljubljana
Funding:	Slovenian Research Agency (ARRS), Slovenia

Development and Optimization of Electroporation Protocol for Extracting
Biotechnologically Relevant Molecules from Bacterial Cells (2014-2017)

Principal investigator:	Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana
Partner:	Dr. Matjaz Peterka, Center of Excellence for Biosensors, Instrumentation and Process Control, Ljubljana
Funding:	Slovenian Research Agency (ARRS), Slovenia

New Approaches of Tumor Radiosensibilization with Gene Therapy (2014-2017)

Principal investigator:	Prof. Gregor Sersa, Institute of Oncology, Ljubljana
Partner:	Assoc. Prof. Tomaz Jarm, Faculty of Electrical Eng., University of Ljubljana
Funding:	Slovenian Research Agency (ARRS), Slovenia

Electrochemotherapy in Treatment of Deep Seated Tumors (2013-2016)

Principal investigator:	Prof. Gregor Sersa, Institute of Oncology, Ljubljana
Partner:	Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana
Funding:	Slovenian Research Agency (ARRS), Slovenia

Development of Novel Technologies for Detection, Quantification and Characterisation of Bacteriophages (2013-2016)

Principal investigator:	Dr. Ales Strancar, BIA Separations Ltd., Ajdovscina, Slovenia
Partner:	Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana
Funding:	Slovenian Research Agency (ARRS), Slovenia

2. OTHER CURRENT PROJECTS [back to the top]

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3. RECENT INTERNATIONAL PROJECTS [back to the top]
(in reverse chronological order)

The Physics of Molecular Delivery by Electroporation of the Stratum Corneum: Local Transport Region Initiation and Evolution (2014-2015)

Principal investigator:	Dr. Sid Becker, University of Canterbury, Christchurch, New Zealand
Slovenian investigators:	Prof. Damijan Miklavčič, Faculty of Electrical Eng., University of Ljubljana Dr. Nataša Pavšelj, Faculty of Electrical Eng., University of Ljubljana Barbara Zorec, Faculty of Electrical Eng., University of Ljubljana
Funding:	Marsden Fund, New Zealand

USA-Slovenian Scientific Cooperation: Treatment planning for electrochemo-
therapy and non-thermal irreversible tissue electroporation (2014-2015)

US partner:	Prof. Rafael V. Davalos, Virginia Tech - Wake Forest Univesity, Blacksburg, Virginia, USA
Slovenian partner:	Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana
Funding:	Slovenian Research Agency (ARRS), Slovenia

German-Romanian-Slovenian Scientific Cooperation: High-Density Microelectrode Arrays for Electrical Stimulation and Electroporation (HDMEA4ELSE) (2014-2015)

German partner:	Dr. Günther Zeck, University of Tübingen, Germany
Romanian partner:	Prof. Eugenia Kovacs, Medical University Carol Davila, Bucharest, Romania
Slovenian partner:	Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana
Funding:	International Bureau at the German Federal Ministry of Education and Research, Germany

French-Slovenian Scientific Cooperation (PROTEUS programme): Electroporation of Planar Lipid Bilayers at Various Temperatures: Experimental and Molecular Dynamics Simulation Study (2013-2014)

French partner:	Dr. Mounir Tarek, Université de Lorrainé, France
Slovenian partner:	Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana
Funding:	National Centre of Scientific Research (CNRS), France Slovenian Research Agency (ARRS), Slovenia

Romanian-Slovenian Scientific Cooperation: Dielectrophoresis as a method for manipulation and characterization of electroporated cells (2012-2013)

Romanian partner:	Dr. Mihaela B. Moisescu, Medical University Carol Davila, Bucharest, Romania
Slovenian partner:	Assoc. Prof. Tadej Kotnik, Faculty of Electrical Eng., University of Ljubljana
Funding:	Autoritatea Nationala pentru Cercetare Stiintifica (ANCS), Romania Slovenian Research Agency (ARRS), Slovenia

COST BM0704: Emerging EMF Technologies and Health Risk Management
(2008-2012)

Participating countries:	Austria, Belgium, Bulgaria, Croatia, Cyprus, Czech Republic, Denmark, Finland, France, Germany, Great Britain, Greece, Hungary, Israel, Italy, Latvia, Macedonia, Malta, Netherlands, Norway, Poland, Portugal, Romania, Slovenia, Spain, Sweden, Switzerland
Funding:	European Commission, Brussels, Belgium

Belgian-Slovenian Cooperation in Science and Technology: The Use of Physical Methods Aimed at Increasing Cutaneous Permeability to Enhance Transdermal Drug Delivery (2011-2012)

Belgian partner:	Prof. Véronique Préat, Catholic University of Louvain, Brussels, Belgium
Slovenian partner:	Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana
Funding:	Slovenian Research Agency (ARRS), Slovenia

French-Slovenian Scientific Cooperation (PROTEUS programme): Optimization of Electroporation Protocols for Gene Transfection In Vitro (2011-2012)

French partner:	Prof. Marie-Pierre Rols, Institute of Pharmacology and Structural Biology, Toulouse, France
Slovenian partner:	Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana
Funding:	National Centre of Scientific Research (CNRS), France Slovenian Research Agency (ARRS), Slovenia

Korean-Slovenian Scientific Cooperation: Imaging of conductivity and current density during electroporation (2011-2012)

Korean partner:	Prof. Eung Je Woo, Kyung Hee University, South Korea
Slovenian partner:	Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana
Funding:	National Research Foundation, Korea Slovenian Research Agency (ARRS), Slovenia

USA-Slovenian Scientific Cooperation: Optimization of pulse parameters for electroporation of cellular organelles (2011-2012)

US partner:	Prof. Thomas Vernier, University of Southern California, Los Angeles, USA
Slovenian partner:	Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana
Funding:	Slovenian Research Agency (ARRS), Slovenia

CRH-BME (TEMPUS IV): Curricula reformation and harmonisation in the field of biomedical engineering (2009-2011)

Project coordinator:	Prof. Nicolas Pallikarakis, University of Patras, Greece
Slovenian partner:	Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana
Other partners:	Partners from twenty European countries
Funding:	European Commission, Brussels, Belgium Slovenian Research Agency (ARRS), Slovenia

Argentinian-Slovenian Cooperation in Science and Technology: Electrochemo-therapy of Tumors: Numerical and Experimental Models (2009-2011)

Argentinian partner:	Prof. Guillermo Ricardo Marshall, University of Buenos Aires, Argentina
Slovenian partner:	Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana
Funding:	Slovenian Research Agency (ARRS), Slovenia

French-Slovenian Scientific Cooperation (PROTEUS programme): Electroporation of Planar Lipid Bilayers; Experimental and Molecular Dynamics Approach (2010-2011)

French partner:	Dr. Mounir Tarek, UMR 7565 CNRS, University Henri Poincaré, Nancy, France
Slovenian partner:	Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana
Funding:	National Centre of Scientific Research (CNRS), France Slovenian Research Agency (ARRS), Slovenia

Romanian-Slovenian Scientific Cooperation: Study of cells electrical properties and functional status after electroporation (2010-2011)

Romanian partner:	Dr. Mihaela Moisescu, Medical University Carol Davila, Bucharest, Romania
Slovenian partner:	Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana
Funding:	Autoritatea Nationala pentru Cercetare Stiintifica (ANCS), Romania Slovenian Research Agency (ARRS), Slovenia

Austrian-Slovenian Cooperation in Science and Technology: Ruthenium Compounds and their Possible Applications in Electrochemotherapy (2009-2010)

Austrian partner:	Prof. Bernhard Klaus Keppler, Inst. of Anorg. Chem., Univ. of Vienna, Austria
Slovenian partners:	Prof. Iztok Turel, Faculty of Chem. and Chem. Technol., University of Ljubljana Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana
Funding:	Slovenian Research Agency (ARRS), Slovenia

Croatian-Slovenian Cooperation in Science and Technology: Numerical Modeling of Electric Field Distribution in Electrochemotherapy of Esophagus Malignant Tumors (2009-2010)

Croatian partner:	Prof. Ratko Magjarevic, Faculty of El. & Comp. Eng., University of Zagreb, Croatia
Slovenian partner:	Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana
Funding:	Slovenian Research Agency (ARRS), Slovenia

French-Slovenian Scientific Cooperation (PROTEUS programme): Nanopulses Electroporation - Mechanisms and Effectiveness (2009-2010)

French partner:	Dr. Lluis M. Mir, Institute Gustave-Roussy, Villejuif, France
Slovenian partner:	Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana
Funding:	National Centre of Scientific Research (CNRS), France Slovenian Research Agency (ARRS), Slovenia

USA-Slovenian Scientific Cooperation: Nano- and microsecond pulse electroporation – comparison and combination (2008-2010)

US partner:	Prof. Thomas Vernier, University of Southern California, Los Angeles, USA
Slovenian partner:	Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana
Funding:	Slovenian Research Agency (ARRS), Slovenia

ANGIOSKIN: DNA Electrotransfer of Plasmids Coding for Antiangiogenic Factors as a Proof of Principle of Non-Viral Gene Therapy for the Treatment of Skin Disease (2005-2009)

Project coordinator:	Dr. Lluis M. Mir, Institute Gustave-Roussy, Villejuif, France
Slovenian partner:	Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana
Other partners:	Dr. Ruggero Cadossi, IGEA S.r.l., Modena, Italy Prof. Michel Marty, Institute Gustave-Roussy, Villejuif, France Prof. Véronique Préat, Catholic University of Louvain, Brussels, Belgium Dr. Julie Gehl, Herlev Hospital, Denmark Prof. Michael P. Schön, University of Würzburg, Germany Dr. Dominique Constantini, BioAlliance Pharma SA, Paris, France Dr. Lone Skov, Gentofte Hospital, Hellerup, Denmark
Funding:	European Commission, Brussels, Belgium

Polish-Slovenian Scientific Cooperation: Electroporation of cells in a
current-controlled mode (2008-2009)

Polish partner:	Prof. Malgorzata Kotulska, Wroclaw University of Technology, Poland
Slovenian partner:	Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana
Funding:	Ministerstwo nauki i szkolnictwa wyższego, Poland Slovenian Research Agency (ARRS), Slovenia

Romanian-Slovenian Scientific Cooperation: Monitoring the functional status of electroporated cells in electrochemotherapeutic strategies (2008-2009)

Romanian partner:	Prof. Eugenia Kovacs, Medical University Carol Davila, Bucharest, Romania
Slovenian partner:	Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana
Funding:	Autoritatea Nationala pentru Cercetare Stiintifica (ANCS), Romania Slovenian Research Agency (ARRS), Slovenia

French-Slovenian Scientific Cooperation (PROTEUS programme): Bioimpedance Spectroscopy (2007-2008)

French partner:	Prof. Mustapha Nadi, Faculty of Sciences, University Henri Poincaré, Vandoeuvre-lès-Nancy, France
Slovenian partner:	Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana
Funding:	National Centre of Scientific Research (CNRS), France Slovenian Research Agency (ARRS), Slovenia

Croatian-Slovenian Cooperation in Science and Technology: Numerical Modeling of Electric Field Distribution in Electrochemotherapy and Electrogene Therapy of Deep Tissues (2007-2008)

Croatian partner:	Prof. Ratko Magjarevic, Faculty of El. and Comp. Eng., University of Zagreb, Croatia
Slovenian partner:	Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana
Funding:	Slovenian Research Agency (ARRS), Slovenia

French-Slovenian Scientific Cooperation (PICS Programme): New Theoretical
Models of Cell and Tissue Electropermeabilization, their Experimental Validation and Technological Applications (2005-2007)

French partners:	Dr. Lluis M. Mir, Institute Gustave-Roussy, Villejuif, France Prof. Justin Teissié, Institute of Pharmacol. and Struct. Biol., Toulouse, France
Slovenian partners:	Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana Prof. Gregor Sersa, Institute of Oncology, Ljubljana
Funding:	National Centre of Scientific Research (CNRS), France Slovenian Research Agency (ARRS), Slovenia

Croatian-Slovenian Cooperation in Science and Technology: Numerical Modeling
of Electrical and Heat Phenomena Accompanying Electrochemotherapy and Electrogenetherapy of Tissues (2005-2006)

Croatian partner:	Prof. Ratko Magjarevic, Faculty of El. and Comp. Eng., University of Zagreb
Slovenian partner:	Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana
Funding:	Slovenian Research Agency (ARRS), Slovenia

COST 281: Potential Health Implications from Mobile Communication Systems (2001-2006)

[visit the official home page of the project]

Participating countries:	Austria, Belgium, Bulgaria, Czech Republic, Croatia, Denmark, Finland, France, Germany, Great Britain, Greece, Hungary, Ireland, Italy, Latvia, Lithuania, Netherlands, Norway, Poland, Slovenia, Spain, Sweden, Switzerland
Funding:	European Commission, Brussels, Belgium

French-Slovenian Scientific Cooperation (PROTEUS programme): Evaluation of Electrical Parameters for Effective Electrochemotherapy and Electrogene Therapy, and Design of Electrochemotherapy in Clinics (2004-2005)

French partner:	Dr. Lluis M. Mir, Institute Gustave-Roussy, Villejuif, France
Slovenian partners:	Prof. Gregor Sersa, Institute of Oncology, Ljubljana (national coordinator) Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana
Funding:	National Centre of Scientific Research (CNRS), France Ministry of Education, Science and Sport, Slovenia

ESOPE: European Standard Operating Procedures for Electrochemotherapy
and Electrogenetherapy (2003-2005)

[visit the official home page of the project]

Funding:

European Commission, Brussels, Belgium

Project coordinator:	Dr. Lluis M. Mir, Institute Gustave-Roussy, Villejuif, France
Slovenian partner:	Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana
Other partners:	Prof. Michel Marty, Institute Gustave-Roussy, Villejuif, France Dr. Julie Gehl, Herlev Hospital, Denmark Prof. Gerald O'Sullivan, Cork Cancer Research Centre, Cork, Ireland Dr. Ruggero Cadossi, IGEA S.r.l., Modena, Italy Prof. Gregor Sersa, Institute of Oncology, Ljubljana, Slovenia
Funding:	European Commission, Brussels, Belgium

French-Slovenian Scientific Cooperation (PROTEUS programme): Engineering and Biophysical Approach to Understanding Cell Electropermeabilization and its Biomedical and Biotechnological Applications (2003-2004)

French partner:	Prof. Justin Teissié, Institute of Pharmacol. and Struct. Biol., Toulouse, France
Slovenian partners:	Prof. Damijan Miklavcic, Fac. of El. Eng., Univ. of Ljubljana (natl. coordinator) Prof. Gregor Sersa, Institute of Oncology, Ljubljana, Slovenia
Funding:	National Centre of Scientific Research (CNRS), France Ministry of Education, Science and Sport, Slovenia

Croatian-Slovenian Cooperation in Science and Technology: Evaluation of Electrochemotherapy and Electrogenetherapy by Means of Bioimpedance Measurements (2003-2004)

Croatian partner:	Prof. Ratko Magjarevic, Faculty of El. and Comp. Eng., University of Zagreb
Slovenian partner:	Prof. Damijan Miklavcic, Faculty of El. Eng., University of Ljubljana
Funding:	Ministry of Education, Science and Sport, Slovenia

CLINIPORATOR: A New Adaptive Generator for DNA Electrotransfer In Vivo
for Gene Therapy (2000-2003)

Project coordinator:	Dr. Lluis M. Mir, Institute Gustave-Roussy, Villejuif, France
Slovenian partner:	Prof. Damijan Miklavcic, Faculty of Electrical Eng., University of Ljubljana
Other partners:	Dr. Antonio Dorati, IGEA S.r.l., Modena, Italy Prof. Eberhard Neumann, University of Bielefeld, Germany Prof. Justin Teissié, Institute of Pharmacol. and Struct. Biol., Toulouse, France Prof. Bertil Persson, University of Lund, Sweden Prof. Véronique Préat, Catholic University of Louvain, Brussels, Belgium Dr. Julie Gehl, Herlev Hospital, Denmark

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